Professor Nam-Trung Nguyen
Liquid marbles as a digital microfluidic lab-on-a-chip platform
Liquid marbles (LMs) are droplets with volume of typically microliters coated with hydrophobic powder. The versatility, ease of use and low cost make LMs an attractive platform for lab on a chip. The talk will report our recent discoveries in the physics of liquid marbles (LMs) that allow them to serve as miniature labs. The talk will first report the generation and contactless manipulation of LMs using dielectrophoresis. The robustness of LMs was investigated in terms of evaporation and structural deformation. We then demonstrated that a LM can survive thermal cycling conditions up to 95°C in a humidity-controlled environment. Successful amplification of DNA with polymerase chain reaction (PCR) will be presented. Finally, three-dimensional cell culture and cryopreservation are presented to show that LMs can also serve as a versatile and scalable bioreactor platform.
Nam-Trung Nguyen received his Dip-Ing, Dr Ing and Dr Ing Habil degrees from Chemnitz University of Technology, Germany, in 1993, 1997 and 2004, respectively. From 1999 to 2012, he has been an Associate Professor with Nanyang Technological University, Singapore. From 2013, he has been serving as a Professor and the Director of Queensland Micro- and Nanotachnology Centre at Griffith University, Australia. He is a Fellow of ASME and a Senior Member of IEEE. He published over 400 journal papers with over 16,000 citations (Google Scholars) and filed 8 patents, of which 3 were granted. The third edition of his bestseller “Fundamentals and Applications of Microfluidics” was published in February 2019.